A Perplexing Case of a Germ Cell Tumor: A Case Report.
J Pediatr Hematol Oncol
; 45(7): e924-e926, 2023 10 01.
Article
in En
| MEDLINE
| ID: mdl-37625143
ABSTRACT
Germ cell tumors (GCTs) are associated with pure gonadal dysgenesis or Swyer syndrome. Swyer syndrome usually presents with primary amenorrhea, streak ovaries, and mixed GCT. However, our patient presented with secondary amenorrhea, normal female external genitalia, and a mixed GCT. Constitutional karyotype was suggestive of 46,XY. Management comprised chemotherapy, followed by surgery. Histopathology was suggestive of dysgerminoma complicating a gonadoblastoma. The purpose of reporting this case is its rarity and the importance of diagnosing an XY karyotype, as the incidence of GCTs is higher in these patients.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovarian Neoplasms
/
Gonadoblastoma
/
Neoplasms, Germ Cell and Embryonal
/
Dysgerminoma
/
Gonadal Dysgenesis, 46,XY
Type of study:
Diagnostic_studies
Limits:
Female
/
Humans
Language:
En
Journal:
J Pediatr Hematol Oncol
Journal subject:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Year:
2023
Type:
Article