Phosphorylation-state dependent intraneuronal sorting of Aß differentially impairs autophagy and the endo-lysosomal system.

ABSTRACT

ABBREVIATIONS AD Alzheimer disease; APP amyloid beta precursor protein; ATG autophagy related; Aß amyloid-ß; CTSD cathepsin D; DAPI 4',6-diamidino-2-phenylindole; EEA1 early endosome antigen 1; FA formic acid; GFP green fluorescent protein; LAMP2 lysosomal-associated membrane protein 2; MAP1LC3/LC3 microtubule-associated protein 1 light chain 3; MAP2 microtubule-associated protein 2; nmAß non-modified amyloid-ß; npAß non-phosphorylated amyloid-ß; pAß phosphorylated amyloid-ß; p-Ser26Aß amyloid-ß phosphorylated at serine residue 26; p-Ser8Aß amyloid-ß phosphorylated at serine residue 8; RAB RAB, member RAS oncogene family; RFP red fluorescent protein; SQSTM1/p62 sequestome 1; YFP yellow fluorescent protein.