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Nanoribbon Biosensor-Based Detection of microRNA Markers of Prostate Cancer.
Ivanov, Yuri D; Malsagova, Kristina A; Goldaeva, Kristina V; Kapustina, Svetlana I; Pleshakova, Tatyana O; Popov, Vladimir P; Kozlov, Andrey F; Galiullin, Rafael A; Shumov, Ivan D; Enikeev, Dmitry V; Potoldykova, Natalia V; Ziborov, Vadim S; Petrov, Oleg F; Dolgoborodov, Alexander Y; Glukhov, Alexander V; Novikov, Sergey V; Grabezhova, Victoria K; Yushkov, Evgeniy S; Konev, Vladimir A; Kovalev, Oleg B; Archakov, Alexander I.
Affiliation
  • Ivanov YD; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia.
  • Malsagova KA; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia.
  • Goldaeva KV; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia.
  • Kapustina SI; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia.
  • Pleshakova TO; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia.
  • Popov VP; Rzhanov Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
  • Kozlov AF; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia.
  • Galiullin RA; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia.
  • Shumov ID; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia.
  • Enikeev DV; Institute for Urology and Reproductive Health, Sechenov University, 119992 Moscow, Russia.
  • Potoldykova NV; Institute for Urology and Reproductive Health, Sechenov University, 119992 Moscow, Russia.
  • Ziborov VS; Joint Institute for High Temperatures of Russian Academy of Sciences, 125412 Moscow, Russia.
  • Petrov OF; Joint Institute for High Temperatures of Russian Academy of Sciences, 125412 Moscow, Russia.
  • Dolgoborodov AY; Joint Institute for High Temperatures of Russian Academy of Sciences, 125412 Moscow, Russia.
  • Glukhov AV; JSC "Novosibirsk Plant of Semiconductor Devices with OKB", 630082 Novosibirsk, Russia.
  • Novikov SV; Associate Printing-and-Publication Centre Technosphera, 125319 Moscow, Russia.
  • Grabezhova VK; JSC "Design Center for Biomicroelectronic Technologies "Vega"", 630082 Novosibirsk, Russia.
  • Yushkov ES; Department for Business Project Management, National Research Nuclear University "MEPhI", 115409 Moscow, Russia.
  • Konev VA; Department of Infectious Diseases in Children, Faculty of Pediatrics, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
  • Kovalev OB; Department of Infectious Diseases in Children, Faculty of Pediatrics, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
  • Archakov AI; Institute of Biomedical Chemistry (IBMC), 119121 Moscow, Russia.
Sensors (Basel) ; 23(17)2023 Aug 30.
Article in En | MEDLINE | ID: mdl-37687982
ABSTRACT
Prostate cancer (PC) is one of the major causes of death among elderly men. PC is often diagnosed later in progression due to asymptomatic early stages. Early detection of PC is thus crucial for effective PC treatment. The aim of this study is the simultaneous highly sensitive detection of a palette of PC-associated microRNAs (miRNAs) in human plasma samples. With this aim, a nanoribbon biosensor system based on "silicon-on-insulator" structures (SOI-NR biosensor) has been employed. In order to provide biospecific detection of the target miRNAs, the surface of individual nanoribbons has been sensitized with DNA oligonucleotide probes (oDNA probes) complementary to the target miRNAs. The lowest concentration of nucleic acids, detectable with our biosensor, has been found to be 1.1 × 10-17 M. The successful detection of target miRNAs, isolated from real plasma samples of PC patients, has also been demonstrated. We believe that the development of highly sensitive nanotechnology-based biosensors for the detection of PC markers is a step towards personalized medicine.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Nucleic Acids / Nanotubes, Carbon / MicroRNAs Type of study: Diagnostic_studies / Screening_studies Limits: Aged / Humans / Male Language: En Journal: Sensors (Basel) Year: 2023 Type: Article Affiliation country: RUSSIA
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Nucleic Acids / Nanotubes, Carbon / MicroRNAs Type of study: Diagnostic_studies / Screening_studies Limits: Aged / Humans / Male Language: En Journal: Sensors (Basel) Year: 2023 Type: Article Affiliation country: RUSSIA