The definition and global epidemiology of nonmobile colistin resistance (NMCR-3) determinants in Aeromonas from 1968 to 2022.
Drug Resist Updat
; 71: 101006, 2023 Nov.
Article
in En
| MEDLINE
| ID: mdl-37703625
ABSTRACT
Polymyxins are the last line of defense in infections caused by multidrug-resistant Gram-negative bacteria. The chromosomal EptA in Aeromonas genus was defined as a nonmobile colistin resistance determinant 3 (NMCR-3). A total of 14 NMCR-3 genotypes were identified. The global prevalence of Aeromonas-borne NMCRs and MCRs indicates an increasing trend from 1968 to 2022. And an index of resistance risk, i.e, the ratio of η = MCR/NMCR, was proposed to evaluate the propagation potential of NMCR-3. The colistin resistance in North America and Europe faced a high risk of increasing incidence of MCR since large proportions of NMCR-3 variants disseminated from Aeromonas sources. We concluded that NMCR-3 variants act natural progenitors for MCR-3/5/7, and the future MCR variant(s) will most likely be MCR-5 or MCR-7, which is also an early warning of next MCR(s) emerging in Aeromonas.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Colistin
/
Aeromonas
Type of study:
Risk_factors_studies
/
Screening_studies
Limits:
Humans
Language:
En
Journal:
Drug Resist Updat
Journal subject:
ANTINEOPLASICOS
Year:
2023
Type:
Article