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First-in-human liver transplantation from a centenarian deceased donor after brain death.
De Simone, Paolo; Ghinolfi, Davide; Palladino, Simona; Catalano, Gabriele; Martinelli, Caterina; Ducci, Juri; Bronzoni, Jessica; Tincani, Giovanni; Balzano, Emanuele; Carrai, Paola; Petruccelli, Stefania; Campani, Daniela; Crocetti, Laura; Lazzeri, Chiara; Biancofiore, Giandomenico; Peris, Adriano.
Affiliation
  • De Simone P; Hepatobiliary surgery and liver transplantation, University of Pisa Medical School Hospital, Pisa, Italy; Department of Surgical, Medical, Biochemical Pathology and Intensive Care, University of Pisa, Pisa, Italy. Electronic address: paolo.desimone@unipi.it.
  • Ghinolfi D; Hepatobiliary surgery and liver transplantation, University of Pisa Medical School Hospital, Pisa, Italy.
  • Palladino S; Hepatobiliary surgery and liver transplantation, University of Pisa Medical School Hospital, Pisa, Italy.
  • Catalano G; Hepatobiliary surgery and liver transplantation, University of Pisa Medical School Hospital, Pisa, Italy.
  • Martinelli C; Hepatobiliary surgery and liver transplantation, University of Pisa Medical School Hospital, Pisa, Italy.
  • Ducci J; Hepatobiliary surgery and liver transplantation, University of Pisa Medical School Hospital, Pisa, Italy.
  • Bronzoni J; Hepatobiliary surgery and liver transplantation, University of Pisa Medical School Hospital, Pisa, Italy.
  • Tincani G; Hepatobiliary surgery and liver transplantation, University of Pisa Medical School Hospital, Pisa, Italy.
  • Balzano E; Hepatobiliary surgery and liver transplantation, University of Pisa Medical School Hospital, Pisa, Italy.
  • Carrai P; Hepatobiliary surgery and liver transplantation, University of Pisa Medical School Hospital, Pisa, Italy.
  • Petruccelli S; Hepatobiliary surgery and liver transplantation, University of Pisa Medical School Hospital, Pisa, Italy.
  • Campani D; Department of Surgical, Medical, Biochemical Pathology and Intensive Care, University of Pisa, Pisa, Italy; Department of Pathology, University of Pisa Medical School Hospital, Pisa, Italy.
  • Crocetti L; Department of Surgical, Medical, Biochemical Pathology and Intensive Care, University of Pisa, Pisa, Italy; Interventional Radiology, University of Pisa Medical School Hospital, Pisa, Italy.
  • Lazzeri C; Regional Center for Organ and Tissue Allocation, Careggi Hospital, Florence, Italy.
  • Biancofiore G; Department of Surgical, Medical, Biochemical Pathology and Intensive Care, University of Pisa, Pisa, Italy; Anesthesiology and Intensive Care, University of Pisa Medical School Hospital, Pisa, Italy.
  • Peris A; Organizzazione Toscana Trapianti, Tuscany Region Welfare Ministry, Florence, Italy.
Am J Transplant ; 24(2): 304-307, 2024 Feb.
Article in En | MEDLINE | ID: mdl-37757913
ABSTRACT
Liver transplantation from elderly donors is expanding due to demand for liver grafts, aging of recipients and donors, and introduction of machine perfusion. We report on a liver transplant from a 100-year-old deceased donor after brain death. The liver was transplanted after the use of hypothermic machine perfusion to a 60-year-old recipient with advanced hepatocellular carcinoma undergoing neoadjuvant immunotherapy. Nine months after the transplant, the patient is alive with a functioning graft and no evidence of acute rejection or tumor recurrence.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Liver Transplantation / Liver Neoplasms Limits: Aged / Aged80 / Humans / Middle aged Language: En Journal: Am J Transplant Journal subject: TRANSPLANTE Year: 2024 Type: Article
Fulltext
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Liver Transplantation / Liver Neoplasms Limits: Aged / Aged80 / Humans / Middle aged Language: En Journal: Am J Transplant Journal subject: TRANSPLANTE Year: 2024 Type: Article