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Third whole-brain radiation therapy for multiple brain metastases. Should it be considered in selected patients?
Lapadula, L; Piombino, M; Bianculli, A; Caivano, R; Capobianco, A; Cacciatore, A; Cozzolino, M; Oliviero, C; D'andrea, B; Mileo, A; Leone, A; Carbone, F; Fochi, N P; Landriscina, M; Colamaria, A; Giordano, G.
Affiliation
  • Lapadula L; Radiation Oncology Department, IRCCS-CROB, Rionero in Vulture, Italy.
  • Piombino M; Radiation Oncology Department AUOC, Policlinico Bari, Italy.
  • Bianculli A; Radiation Oncology Department, IRCCS-CROB, Rionero in Vulture, Italy.
  • Caivano R; Radiation Oncology Department, IRCCS-CROB, Rionero in Vulture, Italy.
  • Capobianco A; Multidisciplinary Oncology, Health Directorate Department, IRCCS Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, Italy.
  • Cacciatore A; Radiation Oncology Department, IRCCS-CROB, Rionero in Vulture, Italy.
  • Cozzolino M; Radiation Oncology Department, IRCCS-CROB, Rionero in Vulture, Italy.
  • Oliviero C; Radiation Oncology Department, IRCCS-CROB, Rionero in Vulture, Italy.
  • D'andrea B; Radiation Oncology Department, IRCCS-CROB, Rionero in Vulture, Italy.
  • Mileo A; Oncology Unit, IRCCS Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, Italy.
  • Leone A; Department of Neurosurgery, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany; Faculty of Human Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Carbone F; Department of Neurosurgery, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany; Division of Neurosurgery, "Riuniti" Hospital, University of Foggia, FG 71121 Foggia, Italy.
  • Fochi NP; Division of Neurosurgery, "Riuniti" Hospital, University of Foggia, FG 71121 Foggia, Italy. Electronic address: fochinicola98@gmail.com.
  • Landriscina M; Unit of Medical Oncology, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
  • Colamaria A; Division of Neurosurgery, Policlinico "Riuniti", Foggia, Italy.
  • Giordano G; Unit of Medical Oncology, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.
Cancer Radiother ; 27(8): 725-730, 2023 Dec.
Article in En | MEDLINE | ID: mdl-37777371
ABSTRACT
Whole brain reirradiation for the treatment of multiple brain metastases has shown promising results. However, concerns remain over the possible neurotoxic effects of the cumulative dose as well as the questionable radiosensitivity of recurrent metastases. A second reirradiation of the whole brain is ordinarily performed in our department for palliative purposes in patients presenting with multiple metastatic brain progression. For this study, an investigational third whole brain reirradiation has been administered to highly selected patients to obtain disease control and delay progression. Clinical outcomes and neurological toxicity were also evaluated.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Radiosurgery / Re-Irradiation Limits: Humans Language: En Journal: Cancer Radiother Journal subject: NEOPLASIAS / RADIOTERAPIA Year: 2023 Type: Article Affiliation country: Italy
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Radiosurgery / Re-Irradiation Limits: Humans Language: En Journal: Cancer Radiother Journal subject: NEOPLASIAS / RADIOTERAPIA Year: 2023 Type: Article Affiliation country: Italy