Palmitoylation of the hemagglutinin of influenza B virus by ER-localized DHHC enzymes 1, 2, 4, and 6 is required for efficient virus replication.

Meng, Xiaorong; Veit, Michael

Meng, Xiaorong; Veit, Michael.

Affiliation

Meng X; Veterinary Faculty, Institute for Virology, Freie Universität Berlin , Berlin, Germany.
Veit M; Veterinary Faculty, Institute for Virology, Freie Universität Berlin , Berlin, Germany.

J Virol ; 97(10): e0124523, 2023 10 31.

Article in En | MEDLINE | ID: mdl-37792001

Subject(s)

Acyltransferases; Endoplasmic Reticulum; Hemagglutinin Glycoproteins, Influenza Virus; Influenza B virus; Lipoylation; Palmitic Acid; Virus Replication; Humans; Acyltransferases/metabolism; Endoplasmic Reticulum/enzymology; Endoplasmic Reticulum/virology; Hemagglutinin Glycoproteins, Influenza Virus/chemistry; Hemagglutinin Glycoproteins, Influenza Virus/genetics; Hemagglutinin Glycoproteins, Influenza Virus/metabolism; Influenza A virus/chemistry; Influenza A virus/metabolism; Influenza B virus/chemistry; Influenza B virus/growth & development; Influenza B virus/metabolism; Influenza, Human/drug therapy; Influenza, Human/virology; Lipoylation/genetics; Mutation; Palmitic Acid/metabolism

Key words

DHHC proteins; acyltransferase; hemagglutinin; influenza A virus; influenza B virus; palmitoylation; protein function; transmembrane region

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Influenza B virus / Virus Replication / Acyltransferases / Palmitic Acid / Hemagglutinin Glycoproteins, Influenza Virus / Endoplasmic Reticulum / Lipoylation Limits: Humans Language: En Journal: J Virol Year: 2023 Type: Article Affiliation country: Germany

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