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177 Lu Radiolabelled AIE Dots for Multimodal Imaging Guided Photothermal/Radiopharmaceutical Tumor Therapy.
Huang, Haoying; Yu, Kaiwu; Husamelden, Elkawad; Zhang, Hong; Mao, Zhengwei; Liu, Shunjie; Zhang, Qinghua; Tian, Mei; Zhang, Haoke; He, Qinggang.
Affiliation
  • Huang H; Department of Nuclear Medicine and PET Center, the Second Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, P. R. China.
  • Yu K; College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310058, P. R. China.
  • Husamelden E; Department of Nuclear Medicine and PET Center, the Second Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, P. R. China.
  • Zhang H; Department of Nuclear Medicine and PET Center, the Second Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, P. R. China.
  • Mao Z; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, P.R. China.
  • Liu S; MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, P.R. China.
  • Zhang Q; Key Laboratory of Polymer Ecomaterial, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P.R. China.
  • Tian M; College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310058, P. R. China.
  • Zhang H; Department of Nuclear Medicine and PET Center, the Second Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, P. R. China.
  • He Q; Department of Nuclear Medicine and PET Center, the Second Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, P. R. China.
Chem Asian J ; 18(23): e202300847, 2023 Dec 01.
Article in En | MEDLINE | ID: mdl-37842968
ABSTRACT
Aggregation-induced emission luminogens (AIEgens) in the second near-infrared region (NIR-II,1000-1700 nm) have shown tremendous potential as theragnostic probe for tumor multimodal diagnostic imaging and combined treatment owing to their programmable optical, structural and functional properties. Herein, we presented a radionuclide 177 Lu-labeled AIEgen, 177 Lu-2TT-oC6B dots, for NIR-II fluorescence and SPECT/CT imaging-guided tumor photothermal and radiopharmaceutical therapy. Intriguingly, 177 Lu-2TT-oC6B self-assembled into 10 nm dots, exhibited high NIR-II fluorescence quantum yield (QY, 1.34 %) and unprecedented photothermal conversion efficiency (PCE, 70.3 %) in vitro, furtherly performed extremely long blood circulation (T1/2 =52.4 h), persistent tumor accumulation and retention in tumor (NIR-II SNR=5.56; SPECT SNR=36.59) via intravenous administration in vivo. Furthermore, upon NIR light activation and 177 Lu irradiation, 177 Lu-2TT-oC6B demonstrated great application potential in synergistic photothermal/radiopharmaceutical tumor therapy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nanoparticles / Neoplasms Limits: Humans Language: En Journal: Chem Asian J Year: 2023 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nanoparticles / Neoplasms Limits: Humans Language: En Journal: Chem Asian J Year: 2023 Type: Article