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Fumagillin inhibits growth of the enteric protozoan parasite Entamoeba histolytica by covalently binding to and selectively inhibiting methionine aminopeptidase 2.
Watanabe, Natsuki; Saito-Nakano, Yumiko; Kurisawa, Naoaki; Otomo, Keisuke; Suenaga, Kiyotake; Nakano, Kentaro; Nozaki, Tomoyoshi.
Affiliation
  • Watanabe N; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
  • Saito-Nakano Y; Department of Parasitology and Antimicrobial Resistance Research Center, National Institute of Infectious Diseases , Tokyo, Japan.
  • Kurisawa N; Department of Chemistry, Faculty of Science and Technology, Keio University , Kanagawa, Japan.
  • Otomo K; Department of Chemistry, Faculty of Science and Technology, Keio University , Kanagawa, Japan.
  • Suenaga K; Department of Chemistry, Faculty of Science and Technology, Keio University , Kanagawa, Japan.
  • Nakano K; Degree Programs in Biology, Graduate School of Science and Technology, University of Tsukuba , Ibaraki, Japan.
  • Nozaki T; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
Antimicrob Agents Chemother ; 67(11): e0056023, 2023 11 15.
Article in En | MEDLINE | ID: mdl-37874291
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parasites / Entamoeba histolytica / Amebiasis Limits: Animals / Humans Language: En Journal: Antimicrob Agents Chemother Year: 2023 Type: Article Affiliation country: Japan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parasites / Entamoeba histolytica / Amebiasis Limits: Animals / Humans Language: En Journal: Antimicrob Agents Chemother Year: 2023 Type: Article Affiliation country: Japan