Elevated circulating PCSK9 level is associated with 28-day mortality in patients with sepsis: a prospective cohort study.
BMC Emerg Med
; 23(1): 127, 2023 10 31.
Article
in En
| MEDLINE
| ID: mdl-37904138
ABSTRACT
OBJECTIVES:
Pro-protein convertase subtilisin/kexin 9 (PCSK9) decreases the clearance of the pathogenic lipids, supporting the potential role of PCSK9 in the prognosis of sepsis.METHODS:
In this prospective cohort study, patients with sepsis were consecutively recruited from 1 to 2020 to 30 September 2021 at the First People's Hospital of Huaihua, China. All the eligible patients were categorized into low-PCSK9 and high-PCSK9 groups, based on their PCSK9 levels at admission. Time-dependent receiver operating characteristic curves and Cox proportional hazards regression were used to evaluate the association between PCSK9 level and 28-day mortality of sepsis.RESULTS:
Of the 203 enrolled patients, 56 (27.59%) died during the 28-day follow-up. The PCSK9 level was positively related to the C-reactive protein level. The cut-off point of PCSK9 levels for 28-day mortality risk was 370 ng/ml. Through comparison between high-PCSK9 (> 370 ng/ml) with low-PCSK9 (≤ 370 ng/ml) groups, the adjusted HR for mortality was 2.56 (95% CI 1.25-5.23, p = 0.01).CONCLUSIONS:
The 28-day mortality of sepsis increased significantly as the baseline circulating PCSK9 level exceeded 370 ng/ml, indicating circulating PCSK9 levels may be a potential biomarker to predict the prognosis of sepsis.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sepsis
/
Proprotein Convertase 9
Limits:
Humans
Language:
En
Journal:
BMC Emerg Med
Journal subject:
MEDICINA DE EMERGENCIA
Year:
2023
Type:
Article