The Reactome Pathway Knowledgebase 2024.
Nucleic Acids Res
; 52(D1): D672-D678, 2024 Jan 05.
Article
in En
| MEDLINE
| ID: mdl-37941124
ABSTRACT
The Reactome Knowledgebase (https//reactome.org), an Elixir and GCBR core biological data resource, provides manually curated molecular details of a broad range of normal and disease-related biological processes. Processes are annotated as an ordered network of molecular transformations in a single consistent data model. Reactome thus functions both as a digital archive of manually curated human biological processes and as a tool for discovering functional relationships in data such as gene expression profiles or somatic mutation catalogs from tumor cells. Here we review progress towards annotation of the entire human proteome, targeted annotation of disease-causing genetic variants of proteins and of small-molecule drugs in a pathway context, and towards supporting explicit annotation of cell- and tissue-specific pathways. Finally, we briefly discuss issues involved in making Reactome more fully interoperable with other related resources such as the Gene Ontology and maintaining the resulting community resource network.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
Knowledge Bases
/
Metabolic Networks and Pathways
Limits:
Humans
Language:
En
Journal:
Nucleic Acids Res
Year:
2024
Type:
Article
Affiliation country:
Canada