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Discovery of KB-0742, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of CDK9 for MYC-Dependent Cancers.
Freeman, David B; Hopkins, Tamara D; Mikochik, Peter J; Vacca, Joseph P; Gao, Hua; Naylor-Olsen, Adel; Rudra, Sonali; Li, Huixu; Pop, Marius S; Villagomez, Rosa A; Lee, Christina; Li, Heng; Zhou, Minyun; Saffran, Douglas C; Rioux, Nathalie; Hood, Tressa R; Day, Melinda A L; McKeown, Michael R; Lin, Charles Y; Bischofberger, Norbert; Trotter, B Wesley.
Affiliation
  • Freeman DB; Kronos Bio, Inc., 301 Binney Street, 2nd Floor East, Cambridge, Massachusetts 02142, United States.
  • Hopkins TD; Kronos Bio, Inc., 1300 So. El Camino Real Suite 400, San Mateo, California 94402, United States.
  • Mikochik PJ; Kronos Bio, Inc., 301 Binney Street, 2nd Floor East, Cambridge, Massachusetts 02142, United States.
  • Vacca JP; Kronos Bio, Inc., 1300 So. El Camino Real Suite 400, San Mateo, California 94402, United States.
  • Gao H; Kronos Bio, Inc., 301 Binney Street, 2nd Floor East, Cambridge, Massachusetts 02142, United States.
  • Naylor-Olsen A; Kronos Bio, Inc., 1300 So. El Camino Real Suite 400, San Mateo, California 94402, United States.
  • Rudra S; Kronos Bio, Inc., 301 Binney Street, 2nd Floor East, Cambridge, Massachusetts 02142, United States.
  • Li H; Kronos Bio, Inc., 1300 So. El Camino Real Suite 400, San Mateo, California 94402, United States.
  • Pop MS; Kronos Bio, Inc., 301 Binney Street, 2nd Floor East, Cambridge, Massachusetts 02142, United States.
  • Villagomez RA; Kronos Bio, Inc., 1300 So. El Camino Real Suite 400, San Mateo, California 94402, United States.
  • Lee C; Naylor Olsen Consulting, LLC, 3369 Saddle Wood Court, Lansdale, Pennsylvania 19446, United States.
  • Li H; TCG Lifesciences Private Limited, Block BN, Plot 7, Salt-lake Electronics Complex, Sector V, Kolkata 700091, West Bengal, India.
  • Zhou M; WuXi AppTec (Tianjin) Co., Ltd., 168 NanHai Road, 10th Avenue, TEDA, Tianjin 300457, P. R. China.
  • Saffran DC; Kronos Bio, Inc., 301 Binney Street, 2nd Floor East, Cambridge, Massachusetts 02142, United States.
  • Rioux N; Kronos Bio, Inc., 1300 So. El Camino Real Suite 400, San Mateo, California 94402, United States.
  • Hood TR; Kronos Bio, Inc., 301 Binney Street, 2nd Floor East, Cambridge, Massachusetts 02142, United States.
  • Day MAL; Kronos Bio, Inc., 1300 So. El Camino Real Suite 400, San Mateo, California 94402, United States.
  • McKeown MR; Kronos Bio, Inc., 301 Binney Street, 2nd Floor East, Cambridge, Massachusetts 02142, United States.
  • Lin CY; Kronos Bio, Inc., 1300 So. El Camino Real Suite 400, San Mateo, California 94402, United States.
  • Bischofberger N; Kronos Bio, Inc., 301 Binney Street, 2nd Floor East, Cambridge, Massachusetts 02142, United States.
  • Trotter BW; Kronos Bio, Inc., 1300 So. El Camino Real Suite 400, San Mateo, California 94402, United States.
J Med Chem ; 66(23): 15629-15647, 2023 12 14.
Article in En | MEDLINE | ID: mdl-37967851
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplasms / Antineoplastic Agents Limits: Adult / Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2023 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplasms / Antineoplastic Agents Limits: Adult / Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2023 Type: Article Affiliation country: United States