Unraveling the lymphatic system in the spinal cord meninges: a critical element in protecting the central nervous system.
Cell Mol Life Sci
; 80(12): 366, 2023 Nov 20.
Article
in En
| MEDLINE
| ID: mdl-37985518
ABSTRACT
The lymphatic vasculature plays a crucial role in fluid clearance and immune responses in peripheral organs by connecting them to distal lymph nodes. Recently, attention has been drawn to the lymphatic vessel network surrounding the brain's border tissue (Aspelund et al. in J Exp Med 212991-999, 2015. https//doi.org/10.1084/jem.20142290 ; Louveau et al. in Nat Neurosci 211380-1391, 2018. https//doi.org/10.1038/s41593-018-0227-9 ), which guides immune cells in mediating protection against tumors (Song et al. in Nature 577689-694, 2020. https//doi.org/10.1038/s41586-019-1912-x ) and pathogens Li et al. (Nat Neurosci 25577-587, 2022. https//doi.org/10.1038/s41593-022-01063-z ) while also contributing to autoimmunity (Louveau et al. 2018) and neurodegeneration (Da Mesquita et al. in Nature 560185-191, 2018. https//doi.org/10.1038/s41586-018-0368-8 ). New studies have highlighted the integral involvement of meningeal lymphatic vessels in neuropathology. However, our limited understanding of spinal cord meningeal lymphatics and immunity hinders efforts to protect and heal the spinal cord from infections, injury, and other immune-mediated diseases. This review aims to provide a comprehensive overview of the state of spinal cord meningeal immunity, highlighting its unique immunologically relevant anatomy, discussing immune cells and lymphatic vasculature, and exploring the potential impact of injuries and inflammatory disorders on this intricate environment.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Central Nervous System
/
Lymphatic Vessels
Language:
En
Journal:
Cell Mol Life Sci
Journal subject:
BIOLOGIA MOLECULAR
Year:
2023
Type:
Article
Affiliation country:
United States