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Water-Soluble Polyoxometal Clusters of Molybdenum (V) with Pyrazole and Triazole: Synthesis and Study of Cytotoxicity and Antiviral Activity.
Konkova, Anna V; Savina, Iulia V; Evtushok, Darya V; Pozmogova, Tatiana N; Solomatina, Maria V; Nokhova, Alina R; Alekseev, Alexander Y; Kuratieva, Natalia V; Eltsov, Ilia V; Yanshole, Vadim V; Shestopalov, Aleksander M; Ivanov, Anton A; Shestopalov, Michael A.
Affiliation
  • Konkova AV; Nikolaev Institute of Inorganic Chemistry SB RAS, 3 Acad. Lavrentiev Ave., Novosibirsk 630090, Russia.
  • Savina IV; Nikolaev Institute of Inorganic Chemistry SB RAS, 3 Acad. Lavrentiev Ave., Novosibirsk 630090, Russia.
  • Evtushok DV; Nikolaev Institute of Inorganic Chemistry SB RAS, 3 Acad. Lavrentiev Ave., Novosibirsk 630090, Russia.
  • Pozmogova TN; Nikolaev Institute of Inorganic Chemistry SB RAS, 3 Acad. Lavrentiev Ave., Novosibirsk 630090, Russia.
  • Solomatina MV; Research Institute of Virology, Federal Research Center of Fundamental and Translational Medicine, 2 Timakova St, Novosibirsk 630117, Russia.
  • Nokhova AR; Research Institute of Virology, Federal Research Center of Fundamental and Translational Medicine, 2 Timakova St, Novosibirsk 630117, Russia.
  • Alekseev AY; Research Institute of Virology, Federal Research Center of Fundamental and Translational Medicine, 2 Timakova St, Novosibirsk 630117, Russia.
  • Kuratieva NV; Research Institute of Applied Ecology, Dagestan State University, 43a Gadzhiyeva St, Makhachkala 367000, Russia.
  • Eltsov IV; Nikolaev Institute of Inorganic Chemistry SB RAS, 3 Acad. Lavrentiev Ave., Novosibirsk 630090, Russia.
  • Yanshole VV; Department of Natural Sciences, Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russia.
  • Shestopalov AM; International Tomography Center SB RAS, 3a Institutskaya Str., Novosibirsk 630090, Russia.
  • Ivanov AA; Department of Physics, Novosibirsk State University, 1 Pirogova St., Novosibirsk 630090, Russia.
  • Shestopalov MA; Research Institute of Virology, Federal Research Center of Fundamental and Translational Medicine, 2 Timakova St, Novosibirsk 630117, Russia.
Molecules ; 28(24)2023 Dec 14.
Article in En | MEDLINE | ID: mdl-38138569
ABSTRACT
Among well-studied and actively developing compounds are polyoxometalates (POMs), which show application in many fields. Extending this class of compounds, we introduce a new subclass of polyoxometal clusters (POMCs) [Mo12O28(µ-L)8]4- (L = pyrazolate (pz) or triazolate (1,2,3-trz or 1,2,4-trz)), structurally similar to POM, but containing binuclear Mo2O4 clusters linked by bridging oxo- and organic ligands. The complexes obtained by ampoule synthesis from the binuclear cluster [Mo2O4(C2O4)2(H2O)2]2- in a melt of an organic ligand are soluble and stable in aqueous solutions. In addition to the detailed characterization in solid state and in aqueous solution, the biological properties of the compounds on normal and cancer cells were investigated, and antiviral activity against influenza A virus (subtype H5N1) was demonstrated.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Water / Influenza A Virus, H5N1 Subtype Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2023 Type: Article Affiliation country: RUSSIA
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Water / Influenza A Virus, H5N1 Subtype Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2023 Type: Article Affiliation country: RUSSIA