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Post-transplant recurrence of focal segmental glomerular sclerosis: consensus statements.
Raina, Rupesh; Jothi, Swathi; Haffner, Dieter; Somers, Michael; Filler, Guido; Vasistha, Prabhav; Chakraborty, Ronith; Shapiro, Ron; Randhawa, Parmjeet S; Parekh, Rulan; Licht, Christopher; Bunchman, Timothy; Sethi, Sidharth; Mangat, Guneive; Zaritsky, Joshua; Schaefer, Franz; Warady, Bradley; Bartosh, Sharon; McCulloch, Mignon; Alhasan, Khalid; Swiatecka-Urban, Agnieszka; Smoyer, William E; Chandraker, Anil; Yap, Hui Kim; Jha, Vivekanand; Bagga, Arvind; Radhakrishnan, Jai.
Affiliation
  • Raina R; Department of Nephrology, Akron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, Ohio, USA; Department of Nephrology, Akron Children's Hospital, Akron, Ohio, USA.
  • Jothi S; Department of Nephrology, Akron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, Ohio, USA.
  • Haffner D; Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
  • Somers M; Division of Nephrology, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Filler G; Department of Pediatrics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada; Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada; Department of Pathology and Laboratory Medicine, Sch
  • Vasistha P; Department of Nephrology, Akron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, Ohio, USA.
  • Chakraborty R; Department of Nephrology, Akron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, Ohio, USA; Department of Nephrology, Akron Children's Hospital, Akron, Ohio, USA.
  • Shapiro R; Recanati/Miller Transplantation Institute, The Mount Sinai Medical Center, New York, New York, USA.
  • Randhawa PS; Department of Pathology, Thomas E Starzl Transplant Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Parekh R; Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
  • Licht C; Division of Pediatric Nephrology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
  • Bunchman T; Pediatric Nephrology and Transplantation, Children's Hospital of Richmond at Virginia Commonwealth University (VCU), Richmond, Virginia, USA.
  • Sethi S; Pediatric Nephrology, Kidney Institute, Medanta, The Medicity Hospital, Gurgaon, Haryana, India.
  • Mangat G; Department of Nephrology, Akron Nephrology Associates/Cleveland Clinic Akron General Medical Center, Akron, Ohio, USA.
  • Zaritsky J; Division of Pediatric Nephrology, Nemours, A.I. duPont Hospital for Children, Wilmington, Delaware, USA.
  • Schaefer F; Department of Pediatric Nephrology, University Children's Hospital Heidelberg, Heidelberg, Germany.
  • Warady B; Division of Nephrology, University of Missouri-Kansas City School of Medicine, Children's Mercy, Kansas City, Missouri, USA.
  • Bartosh S; Department of Pediatrics, University of Wisconsin Medical School, Madison, Wisconsin, USA.
  • McCulloch M; Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
  • Alhasan K; Nephrology Unit, Pediatrics Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia; Pediatric Kidney Transplant Division, Organ Transplant Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
  • Swiatecka-Urban A; University of Virginia Children's Hospital, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
  • Smoyer WE; Center for Clinical and Translational Research and Division of Nephrology, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, USA.
  • Chandraker A; Transplantation Research Center, Kidney and Pancreas Transplantation, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Yap HK; Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Khoo Teck Puat-National University Children's Medical Institute, National University Hospital, Singapore, Singapore.
  • Jha V; George Institute for Global Health, University of New South Wales (UNSW), New Delhi, India; School of Public Health, Imperial College, London, UK; Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, India.
  • Bagga A; Division of Pediatric Nephrology, All India Institute of Medical Sciences, New Delhi, India.
  • Radhakrishnan J; Department of Medicine (Nephrology), Columbia University Medical Center, New York, New York, USA. Electronic address: jr55@cumc.columbia.edu.
Kidney Int ; 105(3): 450-463, 2024 Mar.
Article in En | MEDLINE | ID: mdl-38142038
ABSTRACT
Focal segmental glomerular sclerosis (FSGS) is 1 of the primary causes of nephrotic syndrome in both pediatric and adult patients, which can lead to end-stage kidney disease. Recurrence of FSGS after kidney transplantation significantly increases allograft loss, leading to morbidity and mortality. Currently, there are no consensus guidelines for identifying those patients who are at risk for recurrence or for the management of recurrent FSGS. Our work group performed a literature search on PubMed/Medline, Embase, and Cochrane, and recommendations were proposed and graded for strength of evidence. Of the 614 initially identified studies, 221 were found suitable to formulate consensus guidelines for recurrent FSGS. These guidelines focus on the definition, epidemiology, risk factors, pathogenesis, and management of recurrent FSGS. We conclude that additional studies are required to strengthen the recommendations proposed in this review.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glomerulosclerosis, Focal Segmental / Kidney Transplantation / Nephrotic Syndrome Limits: Adult / Child / Humans Language: En Journal: Kidney Int Year: 2024 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glomerulosclerosis, Focal Segmental / Kidney Transplantation / Nephrotic Syndrome Limits: Adult / Child / Humans Language: En Journal: Kidney Int Year: 2024 Type: Article Affiliation country: United States