Baseline Large-Scale Network Dynamics Associated with Disease Progression in Huntington's Disease.
Mov Disord
; 39(1): 197-203, 2024 Jan.
Article
in En
| MEDLINE
| ID: mdl-38148511
ABSTRACT
BACKGROUND:
Huntington's disease (HD) is a genetically determined disease with motor, cognitive, and neuropsychiatric disorders. However, the links between clinical progression and disruptions to dynamics in motor and cognitive large-scale networks are not well established.OBJECTIVE:
To investigate changes in dynamic and static large-scale networks using an established tool of disease progression in Huntington's disease, the composite Unified Huntington's Disease Rating Scale (cUHDRS).METHODS:
Sixty-four mutation carriers were included. Static and dynamic baseline functional connectivity as well as topological features were correlated to 2-year follow-up clinical assessments using the cUHDRS.RESULTS:
Decline in cUHDRS scores was associated with higher connectivity between frontal default-mode and motor networks, whereas higher connectivity in posterior, mainly visuospatial regions was associated with a smaller decline in cUHDRS scores.CONCLUSIONS:
Structural disruptions in HD were evident both in posterior parietal/occipital and frontal motor regions, with reciprocal increases in functional connectivity. However, although higher visuospatial network connectivity was tied to a smaller cUHDRS decline, increased motor and frontal default-mode connections were linked to a larger cUHDRS decreases. Therefore, divergent functional compensation mechanisms might be at play in the clinical evolution of HD.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Huntington Disease
Limits:
Humans
Language:
En
Journal:
Mov Disord
/
Mov. Disord
/
Movement disorders
Journal subject:
NEUROLOGIA
Year:
2024
Type:
Article
Affiliation country:
Spain