Bridge Cross-Coupling of Bicyclo[1.1.0]butanes.
Org Lett
; 26(1): 360-364, 2024 Jan 12.
Article
in En
| MEDLINE
| ID: mdl-38156902
ABSTRACT
Bicyclo[1.1.0]butanes (BCBs) have gained growing popularity in "strain release" chemistry for the synthesis of four-membered-ring systems and para- and meta-disubstituted arene bioisosteres as well as applications in chemoselective bioconjugation. However, functionalization of the bridge position of BCBs can be challenging due to the inherent strain of the ring system and reactivity of the central C-C bond. Here we report the first late-stage bridge cross-coupling of BCBs, mediated by directed metalation/palladium catalysis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2024
Type:
Article
Affiliation country:
United kingdom