Glutamine addiction in tumor cell: oncogene regulation and clinical treatment.
Cell Commun Signal
; 22(1): 12, 2024 01 03.
Article
in En
| MEDLINE
| ID: mdl-38172980
ABSTRACT
After undergoing metabolic reprogramming, tumor cells consume additional glutamine to produce amino acids, nucleotides, fatty acids, and other substances to facilitate their unlimited proliferation. As such, the metabolism of glutamine is intricately linked to the survival and progression of cancer cells. Consequently, targeting the glutamine metabolism presents a promising strategy to inhibit growth of tumor cell and cancer development. This review describes glutamine uptake, metabolism, and transport in tumor cells and its pivotal role in biosynthesis of amino acids, fatty acids, nucleotides, and more. Furthermore, we have also summarized the impact of oncogenes like C-MYC, KRAS, HIF, and p53 on the regulation of glutamine metabolism and the mechanisms through which glutamine triggers mTORC1 activation. In addition, role of different anti-cancer agents in targeting glutamine metabolism has been described and their prospective applications are assessed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Glutamine
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Cell Commun Signal
Year:
2024
Type:
Article
Affiliation country:
China