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Structurally diverse triterpenoid alkaloids from Buxus rugulosa.
Wang, Yu-Huan; Cui, Le-Tian; Sun, Yu-Jin; Li, Yong-Yi; Luo, Jun; Kong, Ling-Yi.
Affiliation
  • Wang YH; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • Cui LT; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • Sun YJ; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • Li YY; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • Luo J; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • Kong LY; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
J Asian Nat Prod Res ; 26(1): 18-25, 2024 Jan.
Article in En | MEDLINE | ID: mdl-38189299
ABSTRACT
Four new nortriterpenoid alkaloids, namely buxrugulines E-H (1-4), along with five known ones (5-9), were isolated from the twigs and leaves of Buxus rugulosa. Their structures were identified based on extensive NMR data and MS spectroscopic analyses. Our bioassays revealed that compounds 5, 6 and 8 exhibited potent cytotoxicity in vitro against MCF-7 cell lines, with IC50 values ranging from 6.70 to 11.00 µM, respectively.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Buxus / Alkaloids Limits: Humans Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2024 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Buxus / Alkaloids Limits: Humans Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2024 Type: Article Affiliation country: China