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Global emergence of a hypervirulent carbapenem-resistant Escherichia coli ST410 clone.
Ba, Xiaoliang; Guo, Yingyi; Moran, Robert A; Doughty, Emma L; Liu, Baomo; Yao, Likang; Li, Jiahui; He, Nanhao; Shen, Siquan; Li, Yang; van Schaik, Willem; McNally, Alan; Holmes, Mark A; Zhuo, Chao.
Affiliation
  • Ba X; Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Guo Y; State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Moran RA; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
  • Doughty EL; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
  • Liu B; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  • Yao L; State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Li J; State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • He N; State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Shen S; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
  • Li Y; Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, China.
  • van Schaik W; Department of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
  • McNally A; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
  • Holmes MA; Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
  • Zhuo C; Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom. mah1@cam.ac.uk.
Nat Commun ; 15(1): 494, 2024 Jan 12.
Article in En | MEDLINE | ID: mdl-38216585
ABSTRACT
Carbapenem-resistant Escherichia coli (CREC) ST410 has recently emerged as a major global health problem. Here, we report a shift in CREC prevalence in Chinese hospitals between 2017 and 2021 with ST410 becoming the most commonly isolated sequence type. Genomic analysis identifies a hypervirulent CREC ST410 clone, B5/H24RxC, which caused two separate outbreaks in a children's hospital. It may have emerged from the previously characterised B4/H24RxC in 2006 and has been isolated in ten other countries from 2015 to 2021. Compared with B4/H24RxC, B5/H24RxC lacks the blaOXA-181-bearing X3 plasmid, but carries a F-type plasmid containing blaNDM-5. Most of B5/H24RxC also carry a high pathogenicity island and a novel O-antigen gene cluster. We find that B5/H24RxC grew faster in vitro and is more virulent in vivo. The identification of this newly emerged but already globally disseminated hypervirulent CREC clone, highlights the ongoing evolution of ST410 towards increased resistance and virulence.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Escherichia coli Infections / Carbapenem-Resistant Enterobacteriaceae Type of study: Risk_factors_studies Limits: Child / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2024 Type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Escherichia coli Infections / Carbapenem-Resistant Enterobacteriaceae Type of study: Risk_factors_studies Limits: Child / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2024 Type: Article Affiliation country: United kingdom