Ipsilateral orolingual angioedema following rhTNK-tPA administration for acute ischemic stroke.
Am J Emerg Med
; 77: 231.e1-231.e3, 2024 03.
Article
in En
| MEDLINE
| ID: mdl-38272772
ABSTRACT
Recombinant human tenecteplase tissue-type plasminogen activator (rhTNK-tPA), a genetically modified variant of conventional alteplase with longer half-life and higher fibrin specificity, has now emerged as a reasonable choice for thrombolytic treatment of acute ischemic stroke (AIS) in China. Orolingual angioedema is a rare but potentially life-threatening complication of intravenous thrombolysis. Currently, there is no documented evidence of orolingual angioedema occurring after thrombolysis with rhTNK-tPA. In this report, we present a unique case of a 75-year-old Chinese man who developed ipsilateral orolingual angioedema following the administration of rhTNK-tPA for AIS. Our case emphasizes the need for caution when using rhTNK-tPA due to its potential to induce ipsilateral orolingual angioedema.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Ischemia
/
Stroke
/
Ischemic Stroke
/
Angioedema
Limits:
Aged
/
Humans
/
Male
Language:
En
Journal:
Am J Emerg Med
Year:
2024
Type:
Article
Affiliation country:
China