FOXO3a functions as a transcriptional and co-transcriptional splicing regulator in vascular endothelial cell lines.
Gene
; 904: 148221, 2024 Apr 30.
Article
in En
| MEDLINE
| ID: mdl-38286271
ABSTRACT
Recent studies have indicated a connection between Forkhead box O3a protein and coronary artery disease, yet the exact role of FOXO3a in the regulation of metabolic processes and apoptosis in vascular endothelial cells is still unknown. Therefore, we investigated the role of FOXO3a on target genes in a human vascular endothelial cell line. Through the utilization of high-throughput sequencing technology, we analyzed gene expression profiles and alternative splicing patterns in human vascular endothelial cells with FOXO3a over expression. This study identified 419 DEGs between FOXO3a-OE HUVEC model and control cells. KEGG analysis indicated that the upregulated genes were mainly enriched in inflammation-related signaling pathways, and the downregulated genes were enriched in lipid metabolism-related pathways.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Endothelial Cells
/
Forkhead Transcription Factors
Limits:
Humans
Language:
En
Journal:
Gene
Year:
2024
Type:
Article
Affiliation country:
China