Your browser doesn't support javascript.
loading
Borrelia-specific antibody profiles and complement deposition in joint fluid distinguish antibiotic-refractory from -responsive Lyme arthritis.
Bowman, Kathryn A; Wiggins, Christine D; DeRiso, Elizabeth; Paul, Steffan; Strle, Klemen; Branda, John A; Steere, Allen C; Lauffenburger, Douglas A; Alter, Galit.
Affiliation
  • Bowman KA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Wiggins CD; Brigham and Women's Hospital, Division of Infectious Diseases, Boston, MA 02115, USA.
  • DeRiso E; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  • Paul S; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
  • Strle K; Marks Group, Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
  • Branda JA; Tufts University School of Medicine Boston, Boston, MA, USA.
  • Steere AC; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
  • Lauffenburger DA; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Alter G; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
iScience ; 27(2): 108804, 2024 Feb 16.
Article in En | MEDLINE | ID: mdl-38303696
ABSTRACT
Lyme arthritis, caused by the spirochete Borrelia burgdorferi, is the most common feature of late disseminated Lyme disease in the United States. While most Lyme arthritis resolves with antibiotics, termed "antibiotic-responsive", some individuals develop progressive synovitis despite antibiotic therapy, called "antibiotic-refractory" Lyme arthritis (LA). The primary drivers behind antibiotic-refractory arthritis remain incompletely understood. We performed a matched, cross-compartmental comparison of antibody profiles from blood and joint fluid of individuals with antibiotic-responsive (n = 11) or antibiotic-refractory LA (n = 31). While serum antibody profiles poorly discriminated responsive from refractory patients, a discrete profile of B.burgdorferi-specific antibodies in joint fluid discriminated antibiotic-responsive from refractory LA. Cross-compartmental comparison of antibody glycosylation, IgA1, and antibody-dependent complement deposition (ADCD) revealed more poorly coordinated humoral responses and increased ADCD in refractory disease. These data reveal B.burgdorferi-specific serological markers that may support early stratification and clinical management, and point to antibody-dependent complement activation as a key mechanism underlying persistent disease.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: IScience Year: 2024 Type: Article Affiliation country: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: IScience Year: 2024 Type: Article Affiliation country: United States