OCT risk factors for 2-year foveal involvement in non-treated eyes with extrafoveal geographic atrophy and AMD.
Graefes Arch Clin Exp Ophthalmol
; 262(7): 2101-2109, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38326629
ABSTRACT
PURPOSE:
To assess the relationship of optical coherence tomography (OCT) findings and progression to foveal atrophy in a cohort of eyes with extrafoveal geographic atrophy (GA) and age-related macular degeneration (AMD) at inclusion.METHODS:
We retrospectively analyzed 45 participants (45 eyes) with extrafoveal GA at baseline and with 2 years of regular follow-ups. Several OCT qualitative features (i.e., presence of foveal flat pigment epithelium detachment with a thin double layer sign [DLS] and reticular pseudodrusen, GA focality) and quantitative measurements (outer retinal layer thickness, retinal pigment epithelium [RPE] to Bruch's membrane [BM] volume, minimum distance from the central foveal circle, and untransformed GA lesion size area) were assessed at baseline. Logistic regression analyses were carried out to identify independent significant predictors and compute odds ratios (ORs) for the risk of the development of atrophy.RESULTS:
At month 24, 26 eyes (57.8%) developed atrophy in the foveal central circle, while 11 eyes (24.4%) developed atrophy in the foveal central point. Significant independent predictive features for the development of atrophy in the foveal central circle included foveal outer retinal thickness (OR, 0.867; p = 0.015), minimum distance from the foveal central circle (OR, 0.992; p = 0.022), and foveal thin DLS (OR, 0.044; p = 0.036). The only independent predictive feature for the development of atrophy in the foveal central point was the presence of foveal thin DLS (OR, 0.138; p = 0.017).CONCLUSIONS:
We identified OCT risk factors for 2-year foveal atrophy in eyes with untreated extrafoveal GA at baseline.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fluorescein Angiography
/
Visual Acuity
/
Disease Progression
/
Tomography, Optical Coherence
/
Retinal Pigment Epithelium
/
Geographic Atrophy
/
Fovea Centralis
Type of study:
Etiology_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Graefes Arch Clin Exp Ophthalmol
Year:
2024
Type:
Article
Affiliation country:
Italy