Electroactive poly(vinylidene fluoride-trifluoroethylene)/graphene composites for cardiac tissue engineering applications.
J Colloid Interface Sci
; 663: 73-81, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38394819
ABSTRACT
Electroactive materials are increasingly being used in strategies to regenerate cardiac tissue. These materials, particularly those with electrical conductivity, are used to actively recreate the electromechanical nature of the cardiac tissue. In the present work, we describe a novel combination of poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)), a highly electroactive polymer, with graphene (G), exhibiting high electrical conductivity. G/P(VDF-TrFE) films have been characterized in terms of topographical, physico-chemical, mechanical, electrical, and thermal properties, and studied the response of cardiomyocytes adhering to them. The results indicate that the crystallinity and the wettability of the composites remain almost unaffected after G incorporation. In turn, surface roughness, Young modulus, and electric properties are higher in G/P(VDF-TrFE). Finally, the composites are highly biocompatible and able to support cardiomyocyte adhesion and proliferation, particularly surface treated ones, demonstrating the suitability of these materials for cardiac tissue engineering applications.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyvinyls
/
Vinyl Compounds
/
Fluorocarbon Polymers
/
Graphite
/
Hydrocarbons, Fluorinated
Language:
En
Journal:
J Colloid Interface Sci
/
J. colloid interface sci
/
Journal of colloid and interface science
Year:
2024
Type:
Article
Affiliation country:
Portugal