Focusing on the role of protein kinase mTOR in endometrial physiology and pathology: insights for therapeutic interventions.
Mol Biol Rep
; 51(1): 359, 2024 Feb 24.
Article
in En
| MEDLINE
| ID: mdl-38400863
ABSTRACT
The mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase crucial for cellular differentiation, proliferation, and autophagy. It shows a complex role in the endometrium, influencing both normal and pathogenic conditions. mTOR promotes the growth and maturation of endometrial cells, enhancing endometrial receptivity and decidualization. However, it also contributes to the development of endometriosis (EMs) and endometrial cancer (EC), thus emerging as a therapeutic target for these conditions. In this review, we summarize recent research progress on the mTOR signalling pathway in the endometrium. This provides insights into female endometrial structure and function and guides the prevention and treatment of related diseases.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sirolimus
/
Endometriosis
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Mol Biol Rep
Year:
2024
Type:
Article
Affiliation country:
China