Immune-mediated polyarthritis and anterior uveitis secondary to zonisamide administration in a dog with refractory epilepsy.
Vet Med Sci
; 10(2): e1374, 2024 03.
Article
in En
| MEDLINE
| ID: mdl-38403976
ABSTRACT
The objective of this article is to describe a case of suspected zonisamide-induced immune-mediated polyarthritis (IMPA) and anterior uveitis in a dog. A 7-year-old male neutered Siberian Husky with a history of refractory idiopathic epilepsy was presented for cluster seizures. Following the addition of zonisamide to the antiepileptic regime, the dog developed new IMPA and anterior uveitis. Within a few weeks of discontinuation of the zonisamide, the dog's IMPA and anterior uveitis resolved. These immune-mediated conditions were thus presumed to be an idiosyncratic reaction to zonisamide. To our knowledge, this is the first report of IMPA and anterior uveitis in dogs associated with zonisamide administration at its recommended dose.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organophosphorus Compounds
/
Arthritis
/
Uveitis, Anterior
/
Dog Diseases
/
Drug Resistant Epilepsy
Limits:
Animals
Language:
En
Journal:
Vet Med Sci
Year:
2024
Type:
Article
Affiliation country:
United States