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Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.
Shek, Naomi; Choy, Anna-Maria; Lang, Chim C; Miller, Bruce E; Tal-Singer, Ruth; Bolton, Charlotte E; Thomson, Neil C; Chalmers, James D; Bown, Matt J; Newby, David E; Khan, Faisel; Huang, Jeffrey T J.
Affiliation
  • Shek N; Systems Medicine, School of Medicine, University of Dundee, Dundee, UK.
  • Choy AM; Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
  • Lang CC; Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
  • Miller BE; COPD Foundation, Miami, USA.
  • Tal-Singer R; Global Allergy and Airways Patient Platform, Vienna, Austria.
  • Bolton CE; Centre for Respiratory Research, NIHR Nottingham Biomedical Research Centre, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.
  • Thomson NC; School of Infection and immunity, University of Glasgow, Glasgow, Scotland, UK.
  • Chalmers JD; Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
  • Bown MJ; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Newby DE; MRC / University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, Scotland, UK.
  • Khan F; Systems Medicine, School of Medicine, University of Dundee, Dundee, UK.
  • Huang JTJ; Systems Medicine, School of Medicine, University of Dundee, Dundee, UK. jtjhuang@dundee.ac.uk.
NPJ Aging ; 10(1): 15, 2024 Feb 27.
Article in En | MEDLINE | ID: mdl-38413600
ABSTRACT
Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: NPJ Aging Year: 2024 Type: Article Affiliation country: United kingdom
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: NPJ Aging Year: 2024 Type: Article Affiliation country: United kingdom