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A pharynx-to-brain axis controls pharyngeal inflammation-induced anxiety.
Zhao, Wan; Zhang, Ke; Dong, Wan-Ying; Tang, Hao-Di; Sun, Jia-Qiang; Huang, Ji-Ye; Wan, Guang-Lun; Guan, Rui-Rui; Guo, Xiao-Tao; Cheng, Ping-Kai; Tao, Ran; Sun, Jing-Wu; Zhang, Zhi; Zhu, Xia.
Affiliation
  • Zhao W; Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, People's Republic of China.
  • Zhang K; Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, People's Republic of China.
  • Dong WY; Department of Neurobiology and Biophysics, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, People's Republic of China.
  • Tang HD; Department of Neurobiology and Biophysics, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, People's Republic of China.
  • Sun JQ; Laboratory of Anesthesia and Critical Care Medicine Department of Anesthesia and Critical Care Laboratory, National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China.
  • Huang JY; Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, People's Republic of China.
  • Wan GL; Department of Neurobiology and Biophysics, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, People's Republic of China.
  • Guan RR; Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, People's Republic of China.
  • Guo XT; Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, People's Republic of China.
  • Cheng PK; Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, People's Republic of China.
  • Tao R; Department of Neurobiology and Biophysics, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, People's Republic of China.
  • Sun JW; Department of Vascular Surgery, The Second Hospital of Anhui Medical University, Hefei 230601, People's Republic of China.
  • Zhang Z; Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, People's Republic of China.
  • Zhu X; Department of Neurobiology and Biophysics, Hefei National Laboratory for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, People's Republic of China.
Proc Natl Acad Sci U S A ; 121(11): e2312136121, 2024 Mar 12.
Article in En | MEDLINE | ID: mdl-38446848
ABSTRACT
Anxiety is a remarkably common condition among patients with pharyngitis, but the relationship between these disorders has received little research attention, and the underlying neural mechanisms remain unknown. Here, we show that the densely innervated pharynx transmits signals induced by pharyngeal inflammation to glossopharyngeal and vagal sensory neurons of the nodose/jugular/petrosal (NJP) superganglia in mice. Specifically, the NJP superganglia project to norepinephrinergic neurons in the nucleus of the solitary tract (NTSNE). These NTSNE neurons project to the ventral bed nucleus of the stria terminalis (vBNST) that induces anxiety-like behaviors in a murine model of pharyngeal inflammation. Inhibiting this pharynx→NJP→NTSNE→vBNST circuit can alleviate anxiety-like behaviors associated with pharyngeal inflammation. This study thus defines a pharynx-to-brain axis that mechanistically links pharyngeal inflammation and emotional response.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharynx / Pharyngitis Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2024 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharynx / Pharyngitis Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2024 Type: Article