Estrogen related receptor alpha: Potential modulator of age-related macular degeneration.
Curr Opin Pharmacol
; 75: 102439, 2024 04.
Article
in En
| MEDLINE
| ID: mdl-38447458
ABSTRACT
To develop effective therapies for complex blinding diseases such as age-related macular degeneration (AMD), identification of mechanisms involved in its initiation and progression is needed. The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor that regulates several AMD-associated pathogenic pathways. However, it has not been investigated in detail in the ocular posterior pole during aging or in AMD. This review delves into the literature highlighting the significance of ESRRA as a molecular target that may be important in the pathobiology of AMD, and discusses data available supporting the targeting of this receptor signaling pathway as a therapeutic option for AMD.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
ERRalpha Estrogen-Related Receptor
/
Macular Degeneration
Limits:
Humans
Language:
En
Journal:
Curr Opin Pharmacol
Journal subject:
FARMACOLOGIA
Year:
2024
Type:
Article
Affiliation country:
United States