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Teratogenicity of zonisamide and other little-used antiseizure medications.
Vajda, Frank J E; O'Brien, Terence J; Graham, Janet E; Hitchcock, Alison A; Perucca, Piero; Lander, Cecilie M; Eadie, Mervyn J.
Affiliation
  • Vajda FJE; Departments of Medicine and Neurosciences, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3050, Australia; Department of Neuroscience, Monash University, Melbourne, VIC 3004, Australia. Electronic address: vajda@netspace.net.au.
  • O'Brien TJ; Department of Neuroscience, Monash University, Melbourne, VIC 3004, Australia; Department of Neurology, Alfred Health, Melbourne, VIC 3004, Australia.
  • Graham JE; Departments of Medicine and Neurosciences, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3050, Australia.
  • Hitchcock AA; Departments of Medicine and Neurosciences, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3050, Australia.
  • Perucca P; Departments of Medicine and Neurosciences, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC 3050, Australia; Department of Neuroscience, Monash University, Melbourne, VIC 3004, Australia; Department of Neurology, Alfred Health, Melbourne, VIC 3004, Australia; Department of M
  • Lander CM; Royal Brisbane and Women's Hospital and School of Medicine and Biomedical Science, University of Queensland, Brisbane, QLD 4027, Australia.
  • Eadie MJ; Royal Brisbane and Women's Hospital and School of Medicine and Biomedical Science, University of Queensland, Brisbane, QLD 4027, Australia.
Seizure ; 117: 198-201, 2024 Apr.
Article in En | MEDLINE | ID: mdl-38460459
ABSTRACT

PURPOSE:

To investigate the risk of teratogenesis occurring in relation to intrauterine exposure to infrequently used antiseizure medications in Australia.

METHODS:

Analysis of data contained in the Raoul Wallenberg Australian Pregnancy Register of Antiepileptic Drugs.

RESULTS:

There was statistically significant evidence that zonisamide, but not any other of nine infrequently used antiseizure medications in Australia, was associated with a risk of teratogenesis related to the maternal dose of the drug taken in at least the earlier half of pregnancy.

CONCLUSIONS:

The teratogenesis associated with zonisamide, like that associated with topiramate and possibly acetazolamide, may be an expression of a class effect shared among sulphonamide-derived carbonic anhydrase inhibitors that possess anti-seizure activity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Zonisamide / Anticonvulsants Limits: Adult / Female / Humans / Pregnancy Country/Region as subject: Oceania Language: En Journal: Seizure Journal subject: NEUROLOGIA Year: 2024 Type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Zonisamide / Anticonvulsants Limits: Adult / Female / Humans / Pregnancy Country/Region as subject: Oceania Language: En Journal: Seizure Journal subject: NEUROLOGIA Year: 2024 Type: Article