Poly-ϵ-caprolactone scaffold as staple-line reinforcement of rectal anastomosis: an experimental piglet study.
BMC Gastroenterol
; 24(1): 112, 2024 Mar 15.
Article
in En
| MEDLINE
| ID: mdl-38491416
ABSTRACT
PURPOSE:
Rectal anastomoses have a persisting high incidence of anastomotic leakage. This study aimed to assess whether the use of a poly-ϵ-caprolactone (PCL) scaffold as reinforcement of a circular stapled rectal anastomosis could increase tensile strength and improve healing compared to a control in a piglet model.METHOD:
Twenty weaned female piglets received a stapled rectal anastomosis and were randomised to either reinforcement with PCL scaffold (intervention) or no reinforcement (control). On postoperative day five the anastomosis was subjected to a tensile strength test followed by a histological examination to evaluate the wound healing according to the Verhofstad scoring.RESULTS:
The tensile strength test showed no significant difference between the two groups, but histological evaluation revealed significant impaired wound healing in the intervention group.CONCLUSION:
The incorporation of a PCL scaffold into a circular stapled rectal anastomosis did not increase anastomotic tensile strength in piglets and indicated an impaired histologically assessed wound healing.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Caproates
/
Surgical Stapling
/
Anastomotic Leak
/
Lactones
Limits:
Animals
Language:
En
Journal:
BMC Gastroenterol
/
BMC gastroenterol. (Online)
/
BMC gastroenterology (Online)
Journal subject:
GASTROENTEROLOGIA
Year:
2024
Type:
Article
Affiliation country:
Denmark