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Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans.
Scott, Barry; Day, Emily A; O'Brien, Katie L; Scanlan, John; Cromwell, Grace; Scannail, Aine Ni; McDonnell, Marie E; Finlay, David K; Lynch, Lydia.
Affiliation
  • Scott B; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Day EA; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • O'Brien KL; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Scanlan J; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Cromwell G; Division of Endocrinology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Scannail AN; Division of Endocrinology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • McDonnell ME; Division of Endocrinology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Finlay DK; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Lynch L; School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Nat Metab ; 6(4): 651-658, 2024 Apr.
Article in En | MEDLINE | ID: mdl-38499765
ABSTRACT
Metformin, a widely used first-line treatment for type 2 diabetes (T2D), is known to reduce blood glucose levels and suppress appetite. Here we report a significant elevation of the appetite-suppressing metabolite N-lactoyl phenylalanine (Lac-Phe) in the blood of individuals treated with metformin across seven observational and interventional studies. Furthermore, Lac-Phe levels were found to rise in response to acute metformin administration and post-prandially in patients with T2D or in metabolically healthy volunteers.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylalanine / Diabetes Mellitus, Type 2 / Metformin Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Nat Metab Year: 2024 Type: Article Affiliation country: Ireland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylalanine / Diabetes Mellitus, Type 2 / Metformin Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Nat Metab Year: 2024 Type: Article Affiliation country: Ireland