Deaths Associated with Pediatric Hepatitis of Unknown Etiology, United States, October 2021-June 2023.
Emerg Infect Dis
; 30(4)2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38526164
ABSTRACT
During October 2021-June 2023, a total of 392 cases of acute hepatitis of unknown etiology in children in the United States were reported to Centers for Disease Control and Prevention as part of national surveillance. We describe demographic and clinical characteristics, including potential involvement of adenovirus in development of acute hepatitis, of 8 fatally ill children who met reporting criteria. The children had diverse courses of illness. Two children were immunocompromised when initially brought for care. Four children tested positive for adenovirus in multiple specimen types, including 2 for whom typing was completed. One adenovirus-positive child had no known underlying conditions, supporting a potential relationship between adenovirus and acute hepatitis in previously healthy children. Our findings emphasize the importance of continued investigation to determine the mechanism of liver injury and appropriate treatment. Testing for adenovirus in similar cases could elucidate the role of the virus.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Viruses
/
Hepatitis
/
Hepatitis A
Limits:
Child
/
Humans
Country/Region as subject:
America do norte
Language:
En
Journal:
Emerg Infect Dis
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2024
Type:
Article