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Plasma glial fibrillary acidic protein in the visual and language variants of Alzheimer's disease.
Sintini, Irene; Singh, Neha Atulkumar; Li, Danni; Mielke, Michelle M; Machulda, Mary M; Schwarz, Christopher G; Senjem, Matthew L; Jack, Clifford R; Lowe, Val J; Graff-Radford, Jonathan; Josephs, Keith A; Whitwell, Jennifer L.
Affiliation
  • Sintini I; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Singh NA; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Li D; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.
  • Mielke MM; Department of Epidemiology and Prevention, Wake Forest University, Winston-Salem, North Carolina, USA.
  • Machulda MM; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
  • Schwarz CG; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Senjem ML; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Jack CR; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Lowe VJ; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Graff-Radford J; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Josephs KA; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Whitwell JL; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Alzheimers Dement ; 20(5): 3679-3686, 2024 05.
Article in En | MEDLINE | ID: mdl-38528318
ABSTRACT

INTRODUCTION:

Glial fibrillary acidic protein (GFAP) in plasma is a proxy for astrocytic activity and is elevated in amyloid-ß (Aß)-positive individuals, making GFAP a potential blood-based biomarker for Alzheimer's disease (AD).

METHODS:

We assessed plasma GFAP in 72 Aß-positive participants diagnosed with the visual or language variant of AD who underwent Aß- and tau-PET. Fifty-nine participants had follow-up imaging. Linear regression was applied on GFAP and imaging quantities.

RESULTS:

GFAP did not correlate with Aß- or tau-PET cross-sectionally. There was a limited positive correlation between GFAP and rates of tau accumulation, particularly in the language variant of AD, although associations were weaker after removing one outlier patient with the highest GFAP level.

DISCUSSION:

Among Aß-positive AD participants with atypical presentations, plasma GFAP did not correlate with levels of AD pathology on PET, suggesting that the associations between GFAP and AD pathology might plateau during the advanced phase of the disease.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Amyloid beta-Peptides / Tau Proteins / Positron-Emission Tomography / Alzheimer Disease / Glial Fibrillary Acidic Protein Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: Alzheimers Dement Year: 2024 Type: Article Affiliation country: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Amyloid beta-Peptides / Tau Proteins / Positron-Emission Tomography / Alzheimer Disease / Glial Fibrillary Acidic Protein Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: Alzheimers Dement Year: 2024 Type: Article Affiliation country: United States