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Triterpenoid saponins from Bupleurum marginatum and their anti-liver fibrotic activities.
Luo, Ke; Dai, Rong-Ji; Zeng, Yan-Bo; Chang, Wen-Jun; Deng, Yu-Lin; Lv, Fang.
Affiliation
  • Luo K; Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
  • Dai RJ; Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
  • Zeng YB; Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
  • Chang WJ; Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
  • Deng YL; Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
  • Lv F; Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
J Asian Nat Prod Res ; 26(7): 858-864, 2024 Jul.
Article in En | MEDLINE | ID: mdl-38572987
ABSTRACT
A new triterpenoid saponin (1), along with five known compounds (2-6), was isolated from Bupleurum marginatum Wall. ex DC, of which compounds 2-4 were obtained for the first time from this plant. The structures were confirmed by the analysis of 1D, 2D NMR, and HR-ESIMS data, and comparison with previous spectral data. Anti-liver fibrotic activities of the isolates were determined as proliferation inhibition of LPS-induced activation of HSC-T6 in vitro.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saponins / Triterpenes / Bupleurum Limits: Animals Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2024 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saponins / Triterpenes / Bupleurum Limits: Animals Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2024 Type: Article Affiliation country: China