Changing structures, changing paradigms: NELF helps regulate paused or elongating RNA polymerase II.
Mol Cell
; 84(7): 1180-1182, 2024 Apr 04.
Article
in En
| MEDLINE
| ID: mdl-38579674
ABSTRACT
Using cryo-EM and biochemical methods, Su and Vos1 discover an alternative NELF structural state that enables transcription and switches NELF-RNA polymerase II (RNAPII) compatibility with other RNAPII-associated factors that regulate pausing, elongation, termination, and transcription-coupled DNA repair.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription Factors
/
RNA Polymerase II
Language:
En
Journal:
Mol Cell
Journal subject:
BIOLOGIA MOLECULAR
Year:
2024
Type:
Article
Affiliation country:
United States