Protecting Proteins from Desiccation Stress Using Molecular Glasses and Gels.
Chem Rev
; 124(9): 5668-5694, 2024 May 08.
Article
in En
| MEDLINE
| ID: mdl-38635951
ABSTRACT
Faced with desiccation stress, many organisms deploy strategies to maintain the integrity of their cellular components. Amorphous glassy media composed of small molecular solutes or protein gels present general strategies for protecting against drying. We review these strategies and the proposed molecular mechanisms to explain protein protection in a vitreous matrix under conditions of low hydration. We also describe efforts to exploit similar strategies in technological applications for protecting proteins in dry or highly desiccated states. Finally, we outline open questions and possibilities for future explorations.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proteins
/
Desiccation
/
Gels
Limits:
Humans
Language:
En
Journal:
Chem Rev
/
Chem. rev
/
Chemical reviews
Year:
2024
Type:
Article
Affiliation country:
Israel