"The least significant change on bone mineral density scan increased in patients with higher degrees of obesity".
Aging Clin Exp Res
; 36(1): 98, 2024 Apr 23.
Article
in En
| MEDLINE
| ID: mdl-38652346
ABSTRACT
BACKGROUND:
The least significant change (LSC) threshold of 0.03 g/cm² is used to interpret bone mineral density (BMD) scans in the general population. Our working hypothesis was that the current LSC threshold would not be applicable in obese populations.AIMS:
The aim of this study was to calculate the LSC in an obese population.METHODS:
We performed an interventional study among 120 obesity patients, in whom two measurements of BMD were performed at 3 sites. Pairs of measures were used to calculate the LSC, using the Bland and Altman method.RESULTS:
We calculated that the LSC was 0.046 g/cm² at the lumbar spine, 0.069 g/cm² at the femoral neck, and 0.06 g/cm² at the total hip. We also calculated the LSC for each class of obesity and observed an increase in LSC with increasing body mass index (BMI). We calculated a LSC of 0.05 g/cm² in patients with class 2 or class 3 obesity, whereas the LSC in patients with class 1 obesity is similar to the threshold used in the general population.DISCUSSION:
In obese population, like BMD, LSC is higher than the threshold value of the general population, and increases with increasing BMI.CONCLUSION:
LSC of 0.05 g/cm² could be used in clinical practice in patients with class 2 or 3 obesity. These findings should help to improve the interpretation of BMD scans in these patients and optimize their management. TRIAL REGISTRATION NUMBER Comité de Protection des Personnes Ile-de France VII, France.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Absorptiometry, Photon
/
Body Mass Index
/
Bone Density
/
Obesity
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Aging Clin Exp Res
Journal subject:
GERIATRIA
Year:
2024
Type:
Article
Affiliation country:
France