C-C motif chemokine receptor 2 and 7 synergistically control inflammatory monocyte recruitment but the infecting virus dictates monocyte function in the brain.
Commun Biol
; 7(1): 494, 2024 Apr 24.
Article
in En
| MEDLINE
| ID: mdl-38658802
ABSTRACT
Inflammatory monocytes (iMO) are recruited from the bone marrow to the brain during viral encephalitis. C-C motif chemokine receptor (CCR) 2 deficiency substantially reduces iMO recruitment for most, but not all encephalitic viruses. Here we show CCR7 acts synergistically with CCR2 to control this process. Following Herpes simplex virus type-1 (HSV-1), or La Crosse virus (LACV) infection, we find iMO proportions are reduced by approximately half in either Ccr2 or Ccr7 knockout mice compared to control mice. However, Ccr2/Ccr7 double knockouts eliminate iMO recruitment following infection with either virus, indicating these receptors together control iMO recruitment. We also find that LACV induces a more robust iMO recruitment than HSV-1. However, unlike iMOs in HSV-1 infection, LACV-recruited iMOs do not influence neurological disease development. LACV-induced iMOs have higher expression of proinflammatory and proapoptotic but reduced mitotic, phagocytic and phagolysosomal transcripts compared to HSV-1-induced iMOs. Thus, virus-specific activation of iMOs affects their recruitment, activation, and function.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Monocytes
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Mice, Knockout
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La Crosse virus
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Herpesvirus 1, Human
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Receptors, CCR2
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Receptors, CCR7
Limits:
Animals
Language:
En
Journal:
Commun Biol
Year:
2024
Type:
Article
Affiliation country:
United States