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High efficacy of CD19 CAR T cells in patients with transformed Waldenström macroglobulinemia.
Durot, Eric; Roos-Weil, Damien; Chauchet, Adrien; Decroocq, Justine; Di Blasi, Roberta; Gastinne, Thomas; Bensaber, Hedi; Cheminant, Morgane; Jacquet, Caroline; Guidez, Stéphanie; Gros, François-Xavier; Bachy, Emmanuel; Coste, Arthur; Cony-Makhoul, Pascale; Treon, Steven P; Delmer, Alain; Reshef, Ran; Le Gouill, Steven; Castillo, Jorge J; Houot, Roch.
Affiliation
  • Durot E; Department of Hematology, University Hospital of Reims, Reims, France.
  • Roos-Weil D; Sorbonne Université, Hematology, Pitié-Salpêtrière Hospital, Paris, France.
  • Chauchet A; Department of Hematology, University Hospital of Besançon, Besançon, France.
  • Decroocq J; Department of Hematology, Hôpital Cochin, Paris, France.
  • Di Blasi R; Department of Hematology, Hôpital Saint Louis, Paris, France.
  • Gastinne T; Department of Hematology, University Hospital of Nantes, Nantes, France.
  • Bensaber H; Department of Hematology, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France.
  • Cheminant M; Department of Hematology, Hôpital Necker, Paris, France.
  • Jacquet C; Department of Hematology, University Hospital of Nancy, Nancy, France.
  • Guidez S; Department of Hematology, University Hospital of Poitiers, Poitiers, France.
  • Gros FX; Department of Hematology, University Hospital of de Bordeaux, Bordeaux, France.
  • Bachy E; Department of Hematology, Hospices Civils de Lyon, Pierre Bénite, Lyon, France.
  • Coste A; Department of Hematology, University Hospital of Reims, Reims, France.
  • Cony-Makhoul P; Medical and Scientific Department, Lymphoma Academic Research Organisation, Hôpital Lyon-Sud, Pierre-Bénite, France.
  • Treon SP; Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
  • Delmer A; Department of Hematology, University Hospital of Reims, Reims, France.
  • Reshef R; Division of Hematology/Oncology and Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY.
  • Le Gouill S; Department of Hematology, Institut Curie, Paris, France.
  • Castillo JJ; Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
  • Houot R; Department of Hematology, University Hospital of Rennes, Rennes, France.
Blood ; 143(26): 2804-2807, 2024 Jun 27.
Article in En | MEDLINE | ID: mdl-38669635
ABSTRACT
ABSTRACT Histologic transformation of Waldenström macroglobulinemia (HT-WM) carries a poor prognosis with standard treatments. Here, we report the first series of HT-WM treated with chimeric antigen receptor T cells showing a high efficacy and no unexpected toxicity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunotherapy, Adoptive / Waldenstrom Macroglobulinemia / Antigens, CD19 Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Blood Year: 2024 Type: Article Affiliation country: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunotherapy, Adoptive / Waldenstrom Macroglobulinemia / Antigens, CD19 Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Blood Year: 2024 Type: Article Affiliation country: France