RAS G12C Inhibitors: Three Birds with One Stone.

Seale, Tessa; Misale, Sandra

Seale, Tessa; Misale, Sandra.

Affiliation

Seale T; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland.
Misale S; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland.

Cancer Discov ; 14(5): 698-700, 2024 May 01.

Article in En | MEDLINE | ID: mdl-38692265

ABSTRACT

ABSTRACT

SUMMARY:

In this issue, Rubinson, Tanaka, and colleagues demonstrate that differences among G12C inhibitors rely on their ability to covalently bind not only G12C mutant KRAS but also NRAS and HRAS, proposing sotorasib as a potent NRAS G12C inhibitor. See related article by Rubinson et al., p. 727 (6).

Subject(s)

Piperazines; Proto-Oncogene Proteins p21(ras); Pyridines; Pyrimidines; Humans; Proto-Oncogene Proteins p21(ras)/genetics; Proto-Oncogene Proteins p21(ras)/antagonists & inhibitors; Membrane Proteins/antagonists & inhibitors; Membrane Proteins/genetics; Mutation; GTP Phosphohydrolases/genetics; Antineoplastic Agents/therapeutic use; Antineoplastic Agents/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Pyridines / Pyrimidines / Proto-Oncogene Proteins p21(ras) Limits: Humans Language: En Journal: Cancer Discov Year: 2024 Type: Article

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