Association between diabetes and subsequent malignancy risk among older breast cancer survivors.
JNCI Cancer Spectr
; 8(3)2024 Apr 30.
Article
in En
| MEDLINE
| ID: mdl-38718185
ABSTRACT
Type II diabetes is associated with cancer risk in the general population but has not been well studied as a risk factor for subsequent malignancies among cancer survivors. We investigated the association between diabetes and subsequent cancer risk among older (66-84 years), 1-year breast cancer survivors within the linked Surveillance Epidemiology and End Results (SEER)-Medicare database using Cox regression analyses to quantify hazard ratios (HR) and corresponding 95% confidence intervals (95% CI). Among 133â324 women, 29.3% were diagnosed with diabetes before or concurrent with their breast cancer diagnosis, and 10â452 women developed subsequent malignancies over a median follow-up of 4.3 years. Diabetes was statistically significantly associated with liver (HR = 2.35, 95% CI = 1.48 to 3.74), brain (HR = 1.94, 95% CI = 1.26 to 2.96), and thyroid cancer risks (HR = 1.38, 95% CI = 1.01 to 1.89). Future studies are needed to better understand the spectrum of subsequent cancers associated with diabetes and the role of diabetes medications in modifying subsequent cancer risk, alone or in combination with cancer treatments.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Proportional Hazards Models
/
SEER Program
/
Diabetes Mellitus, Type 2
/
Cancer Survivors
Limits:
Aged
/
Aged80
/
Female
/
Humans
Country/Region as subject:
America do norte
Language:
En
Journal:
JNCI Cancer Spectr
Year:
2024
Type:
Article
Affiliation country:
United States