Quality-adjusted life years for HER2-positive, early-stage breast cancer using trastuzumab-containing regimens in the context of cost-effectiveness studies: a systematic review.
Expert Rev Pharmacoecon Outcomes Res
; 24(5): 613-629, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38738869
ABSTRACT
INTRODUCTION:
This study aims to provide a comprehensive assessment of economic and health-related quality of life (HRQoL) outcomes for human epidermal growth factor receptor 2 (HER2)-positive, early-stage breast cancer patients treated with trastuzumab-containing regimens, by focusing on both Incremental Cost-Effectiveness Ratios (ICERs) and quality-adjusted life years (QALYs).METHODS:
A systematic search was conducted across PubMed, Embase, and Scopus databases without language or publication year restrictions. Two independent reviewers screened eligible studies, extracted data, and assessed methodology and reporting quality using the Drummond checklist and Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022), respectively. Costs were converted to US dollars (US$) for 2023 for cross-study comparison.RESULTS:
Twenty-two articles, primarily from high-income countries (HICs), were included, with ICERs ranging from US$13,176/QALY to US$254,510/QALY, falling within country-specific cost-effectiveness thresholds. A notable association was observed between higher QALYs and lower ICERs, indicating a favorable cost-effectiveness and health outcome relationship. EQ-5D was the most utilized instrument for assessing health state utility values, with diverse targeted populations.CONCLUSIONS:
Studies reporting higher QALYs tend to have lower ICERs, indicating a positive relationship between cost-effectiveness and health outcomes. However, challenges such as methodological heterogeneity and transparency in utility valuation persist, underscoring the need for standardized guidelines and collaborative efforts among stakeholders. REGISTRATION PROSPERO ID CRD42021259826.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quality of Life
/
Breast Neoplasms
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Cost-Benefit Analysis
/
Receptor, ErbB-2
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Quality-Adjusted Life Years
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Trastuzumab
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Antineoplastic Agents, Immunological
/
Neoplasm Staging
Limits:
Female
/
Humans
Language:
En
Journal:
Expert Rev Pharmacoecon Outcomes Res
/
Expert rev. pharmacoecon. outcomes res
/
Expert review of pharmacoeconomics and outcomes research
Journal subject:
FARMACOLOGIA
Year:
2024
Type:
Article
Affiliation country:
Netherlands