PET Imaging of Metabolism, Perfusion, and Hypoxia: FDG and Beyond.
Cancer J
; 30(3): 159-169, 2024.
Article
in En
| MEDLINE
| ID: mdl-38753750
ABSTRACT
ABSTRACT Imaging glucose metabolism with [18F]fluorodeoxyglucose positron emission tomography has transformed the diagnostic and treatment algorithms of numerous malignancies in clinical practice. The cancer phenotype, though, extends beyond dysregulation of this single pathway. Reprogramming of other pathways of metabolism, as well as altered perfusion and hypoxia, also typifies malignancy. These features provide other opportunities for imaging that have been developed and advanced into humans. In this review, we discuss imaging metabolism, perfusion, and hypoxia in cancer, focusing on the underlying biology to provide context. We conclude by highlighting the ability to image multiple facets of biology to better characterize cancer and guide targeted treatment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fluorodeoxyglucose F18
/
Positron-Emission Tomography
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Cancer J
Journal subject:
NEOPLASIAS
Year:
2024
Type:
Article
Affiliation country:
Panama