JNJ-7184, a respiratory syncytial virus inhibitor targeting the connector domain of the viral polymerase.
Antiviral Res
; 227: 105907, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38772503
ABSTRACT
Respiratory syncytial virus (RSV) can cause pulmonary complications in infants, elderly and immunocompromised patients. While two vaccines and two prophylactic monoclonal antibodies are now available, treatment options are still needed. JNJ-7184 is a non-nucleoside inhibitor of the RSV-Large (L) polymerase, displaying potent inhibition of both RSV-A and -B strains. Resistance selection and hydrogen-deuterium exchange experiments suggest JNJ-7184 binds RSV-L in the connector domain. JNJ-7184 prevents RSV replication and transcription by inhibiting initiation or early elongation. JNJ-7184 is effective in air-liquid interface cultures and therapeutically in neonatal lambs, acting to drastically reverse the appearance of lung pathology.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Virus Replication
/
Respiratory Syncytial Virus, Human
/
Respiratory Syncytial Virus Infections
Limits:
Animals
/
Humans
Language:
En
Journal:
Antiviral Res
Year:
2024
Type:
Article
Affiliation country:
Belgium