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Reversing Metabolic Dysfunction-Associated Steatotic Liver Disease Promotes Healthy Pediatric Cardiovascular Structures: The PROC Study.
Li, Menglong; Shu, Wen; Zou, Yuchen; Xiao, Huidi; Asihaer, Yeerlin; Guan, Mengying; Khattab, Nourhan; Thapa, Bipin; Sapkota, Suman; Vermund, Sten H; Huang, Dayong; Hu, Yifei.
Affiliation
  • Li M; Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China.
  • Shu W; Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China.
  • Zou Y; Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China.
  • Xiao H; Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China.
  • Asihaer Y; Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China.
  • Guan M; Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China.
  • Khattab N; Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China.
  • Thapa B; Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China.
  • Sapkota S; Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China.
  • Vermund SH; Department of Microbiology of Infectious Diseases, Yale School of Public Health, and Department of Pediatrics, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.
  • Huang D; Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Hu Y; Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China.
Am J Gastroenterol ; 119(8): 1640-1643, 2024 Aug 01.
Article in En | MEDLINE | ID: mdl-38775939
ABSTRACT

INTRODUCTION:

We investigated the impact of metabolic dysfunction-associated steatotic liver disease (MASLD) on cardiovascular structure development in children.

METHODS:

We followed 1,356 children with the mean age of 6.6 years for 4.5 years in Beijing, China. We assessed the association of MASLD with cardiovascular structure (carotid intima-media thickness and left ventricular mass) outcomes at baseline and follow-up.

RESULTS:

Over follow-up, 59 children had persistent MASLD, 109 had incident MASLD (progression), and 35 had normalization of liver health. Children with MASLD normalization showed a significantly lower mean development in carotid intima-media thickness (0.161 vs 0.188 mm) and left ventricular mass (4.5 vs 12.4 g) than children with persistent MASLD.

DISCUSSION:

The control of MASLD was associated with improved cardiovascular structure development.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carotid Intima-Media Thickness Limits: Child / Child, preschool / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Am J Gastroenterol Year: 2024 Type: Article Affiliation country: China
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carotid Intima-Media Thickness Limits: Child / Child, preschool / Female / Humans / Male Country/Region as subject: Asia Language: En Journal: Am J Gastroenterol Year: 2024 Type: Article Affiliation country: China