Cefiderocol utilization in lung transplant recipients at a single center.
Transpl Infect Dis
; 26(4): e14319, 2024 Aug.
Article
in It
| MEDLINE
| ID: mdl-38884771
ABSTRACT
BACKGROUND:
Multidrug-resistant organisms are increasing and are a significant cause of mortality among lung transplant recipients (LTRs). To assist with this issue, novel pharmacotherapies are being developed. This study describes the utilization of a novel antibiotic, cefiderocol (FDC), in LTRs where limited data exists in the current literature. We primarily assessed the clinical indications, duration of therapy, resistance, and adverse effects.METHODS:
Conducted as a single-center retrospective review, this study included adult LTRs who received FDC for at least 24 h. Data, extracted from electronic medical records, encompassed patient demographics, transplant history, antimicrobial dosing, adverse effects, bacterial cultures, and outcomes. The research protocol received institutional review board approval.RESULTS:
FDC exhibited effectiveness against multidrug-resistant Pseudomonas aeruginosa, with 26% 30-day mortality and microbiological clearance observed in nine out of 13 cases. Notably, FDC was used in diverse clinical settings, including for prophylaxis, empiric, and targeted treatment.CONCLUSION:
Further studies are needed to evaluate optimal clinical indications for FDC use in LTRs.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pseudomonas aeruginosa
/
Pseudomonas Infections
/
Cephalosporins
/
Lung Transplantation
/
Drug Resistance, Multiple, Bacterial
/
Transplant Recipients
/
Cefiderocol
/
Anti-Bacterial Agents
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
It
Journal:
Transpl Infect Dis
Journal subject:
TRANSPLANTE
Year:
2024
Type:
Article
Affiliation country:
United States