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A global perspective on the status of clinical metabolomics in laboratory medicine - a survey by the IFCC metabolomics working group.
Fux, Elie; Lenski, Marie; Bendt, Anne K; Otvos, James D; Ivanisevic, Julijana; De Bruyne, Sander; Cavalier, Etienne; Friedecký, David.
Affiliation
  • Fux E; Roche Diagnostics GmbH, Penzberg, Germany.
  • Lenski M; ULR 4483, IMPECS - IMPact de l'Environnement Chimique sur la Santé humaine, Univ. Lille, Institut Pasteur de Lille et Unité Fonctionnelle de Toxicologie, CHU Lille, Lille, France.
  • Bendt AK; Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Singapore.
  • Otvos JD; Lipoprotein Metabolism Laboratory, Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Ivanisevic J; Metabolomics Unit, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
  • De Bruyne S; Department of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium.
  • Cavalier E; Department of Clinical Chemistry, CIRM, University of Liège, CHU de Liège, Liège, Belgium.
  • Friedecký D; Department of Clinical Biochemistry, University Hospital Olomouc, Olomouc, Czechia.
Clin Chem Lab Med ; 62(10): 1950-1961, 2024 Sep 25.
Article in En | MEDLINE | ID: mdl-38915248
ABSTRACT

OBJECTIVES:

Metabolomics aims for comprehensive characterization and measurement of small molecule metabolites (<1700 Da) in complex biological matrices. This study sought to assess the current understanding and usage of metabolomics in laboratory medicine globally and evaluate the perception of its promise and future implementation.

METHODS:

A survey was conducted by the IFCC metabolomics working group that queried 400 professionals from 79 countries. Participants provided insights into their experience levels, knowledge, and usage of metabolomics approaches, along with detailing the applications and methodologies employed.

RESULTS:

Findings revealed a varying level of experience among respondents, with varying degrees of familiarity and utilization of metabolomics techniques. Targeted approaches dominated the field, particularly liquid chromatography coupled to a triple quadrupole mass spectrometer, with untargeted methods also receiving significant usage. Applications spanned clinical research, epidemiological studies, clinical diagnostics, patient monitoring, and prognostics across various medical domains, including metabolic diseases, endocrinology, oncology, cardiometabolic risk, neurodegeneration and clinical toxicology.

CONCLUSIONS:

Despite optimism for the future of clinical metabolomics, challenges such as technical complexity, standardization issues, and financial constraints remain significant hurdles. The study underscores the promising yet intricate landscape of metabolomics in clinical practice, emphasizing the need for continued efforts to overcome barriers and realize its full potential in patient care and precision medicine.
Subject(s)
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Metabolomics Limits: Humans Language: En Journal: Clin Chem Lab Med Journal subject: QUIMICA CLINICA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Year: 2024 Type: Article Affiliation country: Germany

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Metabolomics Limits: Humans Language: En Journal: Clin Chem Lab Med Journal subject: QUIMICA CLINICA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Year: 2024 Type: Article Affiliation country: Germany