Efficacy of administration sequence: Sacituzumab Govitecan and Trastuzumab Deruxtecan in HER2-low metastatic breast cancer.
Br J Cancer
; 131(4): 702-708, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-38918555
ABSTRACT
BACKGROUND:
Current guidelines recommend that patients with HER2-low metastatic breast cancer (MBC) receive sequentially two antibody-drug conjugates (ADCs) Sacituzumab Govitecan (SG) and Trastuzumab Deruxtecan (T-DXd), despite a similar payload. However, the effectiveness of one after another is unknown.METHODS:
ADC-Low is a multicentre, retrospective study evaluating the efficacy of SG and T-DXd, one after another, with or without intermediary lines of chemotherapy, in patients with HER2-low MBC.RESULTS:
One hundred and seventy-nine patients were included the majority with HR-negative tumours received SG first (ADC1) (n = 100/108) while most with HR-positive tumours received T-DXd first (n = 56/71). Median progression-free survival 2 was short 2.7 months (95% CI 2.4-3.3) in the whole population, respectively, 3.1 (95% CI 2.6-3.6) and 2.2 months (95% CI 1.9-2.7) for patients receiving T-DXd or SG second (ADC2). Intermediary lines of chemotherapy between ADC1 and ADC2 had no impact. Primary resistance to ADC2 occurred in 54.4% of patients. Certain patients showed initial response to ADC2.CONCLUSIONS:
Clinical benefit of sequentially administered SG and T-DXd is limited for most patients. Nevertheless, a subset of patients might benefit-on the short term-from a second ADC. Additional studies are needed to identify patients who could benefit from two ADCs with similar payloads.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
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Camptothecin
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Receptor, ErbB-2
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Immunoconjugates
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Antibodies, Monoclonal, Humanized
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Trastuzumab
Limits:
Adult
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Aged
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Aged80
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Female
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Humans
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Middle aged
Language:
En
Journal:
Br J Cancer
/
Br. j. cancer
/
British journal of cancer
Year:
2024
Type:
Article
Affiliation country:
France